[citation needed] The centre was formed by the merger of two Manchester-based arts organisations, Cornerhouse and the Library Theatre Company.

[10] In 2014, filmmaker Danny Boyle became a patron,[11] along with actress and comedian Meera Syal,[12] director Nicholas Hytner, novelist and poet Jackie Kay, filmmaker Asif Kapadia, actress Suranne Jones, artist Phil Collins[13] and visual artist Rosa Barba.

[16] In 2019, HOME was one of the most popular attractions in Manchester with c. 900,000 visits,[17] and Lonely Planet voted it one of the top 500 experiences in the UK ("one of Britain's best arts centres").

[21] In April 2024, HOME cancelled, and then re-instated, an event entitled Voices of Resilience, featuring Palestinian writing and poetry and readings by Kingsley Ben-Adir, Maxine Peake, Kamila Shamsie and Shamshad Khan amongst others.

[22] Citing "recent publicity and security concerns" as rationale for cancellation, over 300 artists and cultural workers wrote to demand HOME reconsider their stance.