It competes in the top-tier Handball-Bundesliga and in the German Handball Cup.

In 1997 they managed a bit of a sensation, when they reached the final of the DHB-Pokal as a second division team, which qualified them for the EHF Cup the following season.

In the 2016-17 season they reached their best league position ever - a 6th place in the Bundesliga with over 40 points.

[2] During this season Philipp Weber was the league top scorer with 224 goals in 34 games[3] and their coach Kai Wandschneider was selected as coach of the season.

HSG Wetzlar's arch-rival is the neighbouring club TV Hüttenberg and games between the clubs are considered as the "Mittelhessenderby".