Fragments of monuments and historical artifacts dated to pre-Christian, early Christian and medieval times have been found in and around Hadrut.

[9] In the 15th and 16th century, many of the fortifications, churches and settlements around Hadrut were destroyed by Ottoman and Safavid forces as they fought for control of the South Caucasus.

In the midst of the 2020 Nagorno-Karabakh conflict, heavy fighting took place in Hadrut, marked by the usage of cluster munitions by the Azerbaijani Army.

[4][5][6] Following the battle, a video of an execution of two unarmed and bound Armenian men in the town by Azerbaijani soldiers spread online, prompting investigations.

[22][23] The town was vandalized and looted by Azerbaijani soldiers after its capture, with people's belongings strewn throughout the streets and the contents of homes upturned.

[25][26] Historical heritage sites in and around the town include the 14th-century church of Spitak Khach’ ('White Cross') located on a hill to the south of Hadrut, on the road towards the neighboring village of Vank,[27][28] the 13th-century bridge of Tsiltakhach’, the Holy Resurrection Church (Surb Harut’yun Yekeghets’i) built in 1621, a cemetery from between the 17th and 19th centuries, as well as a 19th-century bridge, watermill and oil mill.

[29] Sar Sargsyan, Armenian baritone singer The town was home to the Mika-Hadrut Winery, which produced brandy, vodka, and wine.