The MD program was formerly housed at the Queen Lane Campus, near the Henry Ave site of the former Woman's Medical College of Pennsylvania.

To foster a greater sense of community, first year medical students are divided into six learning societies based on local iconic landmarks: Athenaeum; Liberty Bell; Physick House; Rocky Statue; Reading Terminal; and Eakins House.

By 1910, the Woman's Medical College of Pennsylvania "remained as the only school in the United States dedicated to the education of women physicians".

[11] When it eventually became coeducational in the later part of the 20th century, it was thus the longest lasting medical school dedicated exclusively to the education of women physicians.

In 1993, the college became the first medical school in the country to completely integrate women's health issues into its curriculum instead of an occasional lecture or optional elective.

Unfortunately, five years later AHERF, which owned eight Philadelphia hospitals, collapsed in the nation's largest bankruptcy of a non-profit health care organization.

On August 3, 2000, former President Gerald Ford was admitted to the hospital after suffering two minor strokes while attending the 2000 Republican National Convention, but made a quick recovery afterwards.

In 2008, the university broke ground on an addition to the building: The Independence Blue Cross Medical Simulation Center.

The computer-driven robotic mannequins, called high-fidelity patient simulators, exhibit lifelike vital signs, including heartbeats, blood pressures, and body and eye movements.

They can be programmed to display a variety of normal and abnormal conditions and to respond realistically to student interventions such as intubation, drug injection, or cardiac defibrillation.

[18] The Center City Hahnemann Campus, located in downtown Philadelphia, was the main site for the college's clinical education departments in addition to biomedical facilities and other health-science and public health programs.

[21] Located in Berks County, Pennsylvania, Drexel University College of Medicine at Tower Health is affiliated with Reading Hospital, which is a Magnet Recognized acute care facility.

In 2021, Reading Hospital became a 4-year regional campus of the College of Medicine and began training first-year medical students.

[23] After the closure of Hahnemann University Hospital, there was an increased need to consolidate the various Drexel programs that were scattered across the city.

Operating large urban hospitals and small rural private practices, the university provides numerous opportunities for the students to be exposed to many diverse experiences.