The station is situated on the north–south coastal line and is located on Plumer Square (Hebrew: כיכר פלומר, Kikar Plumer) along Independence Road (Hebrew: דרך העצמאות, Derekh HaAtzma'ut) in Haifa's downtown (or Lower-Town).

Haifa Center railway station was built by the British during their Mandate for Palestine and was opened in 1937.

Tzvi Tzafriry, the general manager of Israel Railways, decided to move the head office to Tel Aviv Savidor Station.

Platform numbers increase in an East-to-West direction Haifa Center Railway Station is located next to HaAtzmaut Road, a major public transport artery, thus easily accessible from both bus and Sherut Taxi (share taxi).

Bus lines include: The station is also within a short walking distance from the Port of Haifa's passenger terminal and is near Kikar Pariz (Hebrew: כיכר פריז, Paris Square) – a Carmelit (Haifa's subway) station.