The most senior spiritual leader of the Religious Zionist community at the time of his death, he served as rosh yeshiva (dean) of Yeshivat Or Etzion, and head of the Center for Bnei Akiva Yeshivot.

In 1949, Drukman joined the Israel Defense Forces as part of the Bnei Akiva gar'in (pioneer group) in the Nahal brigade.

In 1952, he became a member of Bnei Akiva's National Directorate, and from 1955 until 1956, he served as an emissary of the organisation to the United States, at Kook's behest.

[2] In 1964, once again with his teacher's encouragement, Drukman founded Yeshivat Or Etzion, a Bnei Akiva-affiliated mamlachti dati (state religious) high school, in Merkaz Shapira.

Throughout this period, he often came into disagreement with senior Haredi rabbis in Israel in regard to his conversion standards, which they deemed to be too lax according to their reading of halakha (Jewish law).

[5] Drukman's efforts were recognised by Benjamin Netanyahu, who said that the rabbi "found a way of bringing hearts together that helped masses of new immigrants to join the ranks of our people".

He was a member of the Knesset committees for the Appointment of Rabbinic Judges, Foreign Affairs and Defense, and Education and Culture during this tenure.

[9] On 10 October 1983, he broke away from the NRP and attempted to form a Knesset faction named the Zionist Religious Camp, but was refused permission to do so by the House Committee.

Drukman even invited Mansour Abbas to his home, in order to explore the possibility of including the United Arab List in a narrow right-wing coalition.

[2] On the other hand, Drukman urged his followers to refrain from taking part in a massive protest against conscription of yeshiva students that was held in Jerusalem in 2014.

[13] Drukman did not support a controversial letter penned by rabbis in 2010 that called for Jews to refrain from letting homes to Arabs.

[2] Drukman lived in Merkaz Shapira with his wife Sarah, one of the first religious women to graduate as a physician from the Hebrew University of Jerusalem.