It is situated on the west side of the town, on the historical main road to Eaglesham and Kilmarnock.
Nearby roads connect Hairmyres to the major A726 Queensway/Glasgow Southern Orbital dual carriageway.
Neighbouring areas include Gardenhall, Mossneuk, Jackton, Peel Park, and Westwood.
Falling under the council's East Kilbride West ward,[1] it gives its name to University Hospital Hairmyres, the general hospital for the town and surrounding area which originally opened in 1904, long before East Kilbride was developed as a new town after World War II.
Next to Hairmyres Station is Abercrombie House, one of the headquarters of the Foreign, Commonwealth and Development Office.