Hakim Syed Muhammad Karam Hussain (1870–25 June 1953) (Urdu: حکیم سید کرم حسین) was an Unani practitioner from Tijara, Alwar.

In Meerut, he took expertise, knowledge and proficiency on ‘Unani Tibb’ from two leading practitioners 'Hakim Mohammad Hasan Haziq' and 'Hakim Baldev Sahai'.

The following Persian commemorative inscription can still be seen at the main entrance of his 'Haveli Qadeem' at Tijara: بحمداللھ بدور شاہ اکبر خلا ئق از غم ايا م وا رفت بحکمش در تجارہ گشت بندے

کہ پيشش گنبد گردوں بود ستPraise be the God, thou the 'Great Emperor' Gone from the world of sorrow By his order, took a stroll in Tijara

That he may take rest before reaching destinationThe above qata was written at the time when Emperor Akbar visited Tijara while moving to Fatehpur Sikri from Delhi.

Hakim Syed Karam Husain also assisted Maulana Mohammad Ilyas in many occasions when he visited nearby towns of Mewat.

Similarly, he helped in the publication of general books such as 'Qutub al Madar Talifat Shikwah' by Maulana Syed Ali Shikwa nabirah Maulana Syed Shah Jurat Ali Arghwani of Makanpur, 'Swanehumri Kalyari' by Mohammad Ashiq Ali, 'Risalah Islahul Milad' by Maulana Qari Abdul Latif Khan (Teacher, Madrasa Aaliya, Agra), 'Gulzar Risalat wa Guldasta-e Shahadat' by Qazi Zakiruddin, 'Nasihatul Muslamin al Maroof Musaddas Kabiruddin' by Aziz Kabiruddin Kalim, 'Kashiful Asrar' by Peerji Ahmad Shah Rampuri, 'Masnawi Farishta Rahmat' and 'Anjam Mohabbat' by Maulana Hakim Mohammad Ahmad Alwari and 'Gulshan Sairul Mashhoor ba Yaadgar Darbar Alwar'.

She inherited all the good qualities from her father, Hussainuddin (died on 11 Dhu al-Hijjah 1278 AH / 1861 AD), a man of horse business from Hyderabad.

With him, his wife (Mrs. Hakimun Nisa), sister (Mrs. Anwari Begum), elder son (Hakim Syed Atiqul Qadir), and others such as Khwaja Kamaluddin (Alias Mian Kallan Shah), Qazi Saeeduddin and Mrs. Zaeefa Khatoon were there.

[7] After his demise, he was laid to rest adjacent to the grave of his wife Hakimun Nisa, who herself died at the age of 81 years on 14th Rabiulawwal 1370 AH/1950AD, in his family graveyard located at Church Road, Mohallah Jinsi, Bhopal.