[2] Foote began her stage career in 1982, when she was cast in the role of "Sophia" in A Little Family Business on Broadway, starring Angela Lansbury.

Father and daughter later collaborated on Talking Pictures, Night Seasons, Laura Dennis, When They Speak of Rita, The Last of the Thorntons, The Carpetbagger's Children, The Day Emily Married, The Trip to Bountiful, for which she won the Lucille Lortel Award for Outstanding Featured Actress and was nominated for the Outer Critics Circle Award for Outstanding Featured Actress in a Play, and Dividing the Estate, for which she won the 2008 Richard Seff Award and was nominated for the 2009 Tony Award for Best Performance by a Featured Actress in a Play.

She was appearing in the Hartford Stage production of her father's theatrical adaptation of the Harper Lee novel To Kill a Mockingbird when he died.

[4] Foote appeared in The Orphans' Home Cycle off-Broadway in 2009, receiving an Outer Critics Circle Award nomination, Outstanding Featured Actress in a Play.

Foote's movie career has been limited to small roles in C.H.U.D., Walking to the Waterline, Friends with Money, and Paranormal Activity 3, among others.