The district capital is Hambantota town; the administrative headquarters are there as well as the center of salt production.

Other prominent towns include Tangalle, Ambalantota, Sooriyawewa, Tissamaharama, and Beliatta.

Before modern development took place after the country gained independence in 1948, the agriculture in the district was characterised by swidden cultivation (chena or slash-and-burn) and, to some extent, paddy cultivation on non-irrigated land.

Leonard Woolf's Village in the Jungle provides a highly interesting and insightful account of the people, the land and issues of concern during the British Colonial period as he worked as an assistant government agent for Hambantota.

The area has traditionally been home to Sinhalese and Sri Lankan Malay people, who collectively make up 98% of the district's population.