Hamilton is a census-designated place and unincorporated community in Monroe County, Mississippi, United States.

[4] The community of Hamilton, also referred to as "Old Hamilton",[5] is approximately 2 miles (3 km) east of the larger community of New Hamilton, established in the late 1880s with the arrival of the Kansas City, Memphis and Birmingham Railroad.

Aberdeen, the county seat, is 11 miles (18 km) to the northwest.

[1] Cedar Grove Creek forms the southeast edge of the community, while Wilson Creek runs just west of the town center.

The two creeks join at the southwest corner of the community to form McKinley Creek, a short west-flowing tributary of the Tombigbee River.