Hamilton GO Centre is a Streamline Moderne building designed by New York architects Fellheimer & Wagner.

Passenger service on the TH&B was discontinued on April 26, 1981, and the TH&B merged into the Canadian Pacific Railway in 1987, leaving the facility disused.

In the early 1990s, GO Transit provided service out of two facilities in Hamilton: trains were routed along the CN Grimsby subdivision to the Hamilton CNR Station 1.6 km to the north, and buses operated from an older bus station on the northern edge of Hamilton's Central Business District (CBD) at John Street North and Rebecca Street.

The seasonal route 51 University continued to stop inside the station's bus terminal.

Via Rail trains do not serve Hamilton, but interchange with the GO line at Aldershot.