It is operated by Hamilton Health Sciences and is formally affiliated with the Michael G. DeGroote School of Medicine at McMaster University.

[3] HGH is one of the largest cardiac surgical centres in Canada, performing over 1,600 open heart surgeries annually.

This union formed one of the largest teaching hospitals in Ontario, operating across four sites with approximately 8,000 employees and 1,000 physicians.

[7] Hamilton General Hospital is a regional centre specializing in cardiac and vascular care, neuroscience, trauma and burn treatment, stroke and rehabilitation.

Also located at the General site are the Regional Rehabilitation Centre and the David Braley Cardiac, Vascular and Stroke Research Institute.