The Aggies have won six AHSAA state championships, including women's basketball in 1990 and men's cross country in 1987, 1988, 1989, 1990, and 1991.

All Aggie athletic events take place at campus venues excluding golf, which competes at the Pikeville Country Club located south of Hamilton.

Hamilton has also maintained rivalries with the Winfield Pirates, which also compete in Region 5, and the Haleyville Lions of Winston County.

The Aggie Band has traveled to Walt Disney World to perform in the Magic Kingdom, Universal Orlando, and the Allstate Sugar Bowl in New Orleans, Louisiana.

The band recently traveled with the Hamilton Aggies to Auburn, Alabama to perform at the AHSAA Super 6 3A Football State Championship at Jordan–Hare Stadium.