The toponym for Hampton Poyle might be: In the reign of Edward the Confessor in the 11th century there were five manors at Hamtone, each held by a different Anglo-Saxon thegn.

The Domesday Book of 1086 records that these had been combined into a single manor of 10 hides held of the King by a person called Jernio or Gernio.

Hampton Poyle passed to his daughter Jane, who was the wife of Ambrose Dormer of Ascot.

In 1625 Hampton Poyle manor was divided into four quarters, but one daughter sold her share to her sister Bridget, who was the wife of the politician Sir Henry Croke.

[1] Henry's son Robert Croke was a politician who was a Royalist in the English Civil War.

[1] In 1717 John West junior's widow Elizabeth and his mortgagees sold Hampton Poyle to Arthur Annesley, 5th Earl of Anglesey.

[5] In the 14th century north and south aisles of two bays were added to the nave and the present chancel arch was inserted.

This style of lively 14th-century sculpture is more common further north in Oxfordshire,[5] including Adderbury, Alkerton, Bloxham and Hanwell.

[6] At the east end of the north aisle is another relief of a human face, forming a corbel that supports a piscina.

Medieval stained glass, made about 1400–30, survives in four small lights at the top of the window.

[1] In the south aisle is an 18th-century monument by Peter Scheemakers for Christopher Tilson (1669–1742), who throughout his adult life was a clerk to HM Treasury.

[5] The church building was restored in 1844 and again in 1870, on the latter occasion under the direction of the Gothic Revival architect GE Street.

[8] St Mary's is now part of the Church of England parish of Kidlington with Hampton Poyle.

[10][11] In 2014 the village adopted a flag based on the Arms of Walter de la Poyle.

[1] The rebels planned to murder landowners including the lord of the manor of Hampton Gay and then to march on London.