It is named after John Stephen Hampton, the Governor of Western Australia from 1862 to 1868.

[1] It continues into Ord Street at the north east corner of Fremantle Prison at Knutsford Street.

Heritage buildings and operations in historical properties occur along the length of the road; they include the Fremantle Children's Literature Centre,[2] Hampton Road reserve,[3] Bundi Kudja,[4] and St Pauls Anglican Church in Beaconsfield.

[5][6] At the Cockburn Road and Rockingham Road intersection, which forms the southern terminus of the road, traffic bound for Fremantle arrives from Spearwood and Kwinana further south, and is brought through a high-density residential area, and past Fremantle Hospital and Fremantle Prison, two of Fremantle's landmarks.

All intersections below are controlled by traffic signals unless otherwise indicated.