She made various commercial films (CF) and music videos before gaining wider attention in 2003, when she appeared in hit Korean television dramas All In and Dae Jang Geum.

[5] A car accident on the set of Wolf seriously injured Han and her co-star Eric Mun,[6][7] causing the drama to be delayed repeatedly[8] until the decision was finally made to discontinue it with only three episodes aired.

After a long recovery for Mun, the two actors reunited instead in the drama Super Rookie Ranger (also known as Invincible Parachute Agent or Korea Secret Agency).

[10] Known for her sweet, innocent and fragile image and her depictions of good girls,[11] Han surprised audiences with her performance as a sexy femme fatale in Detective K: Secret of the Virtuous Widow.

[21] In 2014, she starred in the opposites-attract romantic comedy film The Plan Man, about a methodical, mysophobic librarian who falls for a spontaneous, adventurous musician.

[24] Han next reunited with The Fatal Encounter co-star Hyun Bin in the 2015 suspense series Hyde Jekyll, Me, in the role of a circus master who falls for a theme park owner with split personality disorder.

[27] In 2018, Han starred in the film Miss Baek, playing the titular protagonist; an ex-convict who is emotionally closed up due to the social stigma.

On November 17, 2023, SBS confirmed that Han would star in the romance drama Love Scout as Kang Ji-yoon, CEO of a successful headhunting company.

[40][41][42] A Social Welfare major from Seoul Women's University, Han is widely known for actively participating in volunteer work and fund drives, mostly through the relief organization Join Together Society.