[4] Zagorová first attracted attention in 1963 in the singing competition Hledáme nové talenty, where she was accompanied by the orchestra of Gustav Brom.

In the years 1964–1968, she studied and subsequently graduated in acting at the Janáček Academy of Music and Performing Arts in Brno.

She also sang in the ensemble Sodoma-Gomorrah (Zagorová, Jiří Štědroň, Viktor Sodoma) and she began collaborating with the Václav Zahradník Orchestra, with which she recorded her first album Bludička (1970).

From 1980 to 1986, she performed with the dance and singing duo of Petr Kotvald and Stanislav Hložek, and in 1986, she began collaborating with musician and composer Karel Vágner.

During this period, Zagorová recorded seven studio albums, with the input of numerous established as well as up-and-coming composers, including Petr Hapka.

In June 1989, Zagorová signed the "Několik vět" petition, in which Charter 77 demanded the release of political prisoners and freedom of speech.

She resisted pressure to repeal her signature, instead standing her ground with the words "There was nothing [in the petition] with which a decent person would disagree".

She sang in public for the first time since the fall of the Communist regime in November 1989, together with Jaroslav Hutka, at Wenceslas Square in Prague.

In 2007, she performed on stage in Václav Patejdl's musical Jack the Ripper, and two years later, in Michal David's Mona Lisa.

In 2010, public broadcaster Czech Television and Supraphon published a biographical book with a DVD and CD entitled Legenda – Hana Zagorová – Málokdo ví.