They wrote the song with J Bach, Sarah Solovay, Shawn Charles, and the producers, Elof and Pink Slip, with Ben E. King, Jerry Leiber, and Mike Stoller receiving credits due to the interpolation of "Stand by Me" (1961).

A doo-wop song in the style of Trainor's usual music, it describes a romance between Derulo and his neighbor as he invites her over to his house.

The accompanying music video features an appearance by Paris Hilton, and it depicts Derulo and Trainor adapting to living on a farm.

"[3] Derulo and Trainor both achieved popularity on video-sharing service TikTok in subsequent years; Derulo achieved the viral song "Savage Love (Laxed – Siren Beat)" (2020), while Trainor experienced commercial success with her viral TikTok song "Made You Look" (2022).

[6] Derulo and Trainor wrote the song, titled "Hands on Me", with J Bach, Sarah Solovay, Shawn Charles, Kyle Buckley, and Elof Loelv, with Ben E. King, Jerry Leiber, and Mike Stoller receiving credits due to the interpolation.

[11][12][13] In February 2024, the song was included on Derulo's fifth studio album, Nu King, and reprised on its 2024 supporting concert tour.

[16][17] During her verse, Trainor states that it has "been such a long time since I been lucky", a reference to her being unable to have sex for a while in real life due to pelvic floor damage.

[17][16][18] American Songwriter's Alex Hopper called "Hands on Me" a "sultry revamp" and thought it was in both Derulo and Trainor's wheelhouse.

[15] In a more negative review, Brasil described the interpolation as abysmal and the song as "horny housewife music", adding that its generic production sounded like an artificial intelligence creation and something Trainor could have released years earlier.

[18] Chris Willman of Variety likened "Hands on Me" to a horror movie and the lyrical storyline to old-school pornography; he opined that it would not resonate with audiences over the age of nine and could potentially ruin "Stand by Me" for its listeners.