She is known for her support of her spouse in the fight for an independent Ukraine during the Great Northern War and took responsibility for his affairs during his diplomatic missions in Europe.
She was the daughter of Pavlo Hertsyk, a Poltavan colonel and General Osavul, and his wife Iryna Yablons`ka.
Anna had already given birth to three sons by 1711, one of whom was the godson of the Swedish king Charles XII (Yakiv), and the other - Ivan Mazepa (Hryhor).
During their exile, it was Hanna who assumed most of the responsibility for the children (their family by now numbered seven) while Pylyp traveled all over Europe in search of international support for the liberation of Ukraine and the unification of its two parts.
She, along with her son Hryhor, was in correspondence with the various German princes, Polish magnates and the Kings of Sweden, trying to help in the affairs of her husband.