She debuted as an actress in 1997 in the BR series Aus heiterem Himmel, where she played the role of Miriam "Mimi" Pauly at the beginning of the fourth and last season.

She took over the clip show on musicbox channel (now known as Tele 5) with her sister Sara at the end of 2002; at that time she also started studying Communication Sciences in Vienna.

In 2003 she also had a part in Unter Verdacht: Beste Freunde and a smaller role in the comedy Tramitz & Friends.

Her roles became more ambitious with the television film Emilia – Die zweite Chance, where she played a patient with borderline personality disorder.

In 2007, Herzsprung played terrorist Susanne Albrecht in The Baader Meinhof Complex as well as the leading role of Daniela in the film 10 Seconds.