CF is defined by the SNP P143, and its existence and distribution are inferred from the fact that haplogroups descended from CF include most human male lineages in Eurasia, Oceania, and The Americas.

CF descends from CT (CT-M168), and is the sibling of DE.

In the year 2017, C-M217 (C2) & C-M130 were reported among males belonging to the Shan peoples, who are concentrated in central-east Burma (as well as neighboring parts of China, Laos and Thailand).

[3] However, the researchers concerned (Brunelli et al.) did not rule out all other subclades of CF, such as haplogroup F, in these particular cases.

[citation needed] (In haplogroup F2 has previously been identified in the same geographical region.