[2] The film features Radnor, Malin Åkerman, Kate Mara, Zoe Kazan, Michael Algieri, Pablo Schreiber, and Tony Hale, in the story of a group of young New Yorkers, struggling to balance love, friendship, and their encroaching adulthoods.

Sam's cousin Mary Catherine considers leaving New York for California after her boyfriend Charlie tells her about a promising job offer in Los Angeles.

Rasheen is finally placed with a new foster family, but Sam keeps tabs on his new situation, including providing the boy with drawing materials when he learns of his artistic abilities.

[17] Wesley Morris of The Boston Globe wrote though the film is "frequently funny and occasionally brilliant", the subplot with Rasheen is underdeveloped and "treats Rashaan [sic] like a puppy, a token of Sam’s worthiness as a person.

[18][19] John Anderson of Variety praised the production values and the performance of Åkerman, but wrote "the characters are uniformly annoying, their stories insubstantial and the tone one of smug contentment.

"[20] Writing for the Los Angeles Times, Sam Adams critiqued the film’s plot contrivances and commented, "Treating their problems like they’re the most important crises in the world is what people in their 20s do, but that doesn’t mean we have to go along for the ride.

"[22] Mick LaSalle of the San Francisco Chronicle praised the film and wrote, "There's a point in life where being young starts to get old, but being adult seems like too much of a risk, and Happythankyoumoreplease presents people at that juncture - right before they take the leap.