It is the city's main zone for science-based and technology companies, among them Intel, Teva, NDS (now Cisco), RAD Data, Mobileye, Ophir Optronics, Sandvine, Radware, IDT Global Israel, Medtronic, SATEC, Johnson and Johnson and more.

[6] The first major international corporation to establish a base at Har Hotzvim was Intel, which opened its Fab 8 semiconductor manufacturing plant in 1985.

[9] This angered the Haredi Jewish community living in nearby religious neighborhoods, who strictly observe the Sabbath laws.

Eventually representatives of the Haredi community reached an agreement with Intel to keep the plant open on Saturdays, but allow only non-Jews to work.

[10] In July 2011 Haredi United Torah Judaism party in the Jerusalem city council proposed to clear the area for new residential development for their community, an offer that was firmly rejected by Jerusalem's mayor Nir Barkat[11] In 2015 the Bank of Israel moved its headquarters and activity to the park, due to renovations in its facility in Givat Ram.