Harbour Centre is a skyscraper in the central business district of Downtown Vancouver, British Columbia, Canada which opened in 1977.

The "Lookout" tower atop the office building makes it one of the tallest structures in Vancouver and a prominent landmark on the city's skyline.

It is steps away from Waterfront Station, a major multi-modal transit hub which serves as the Downtown Vancouver terminal for various TransLink operations including SeaBus, West Coast Express, SkyTrain, Canada Line and buses.

Simon Fraser University operates its downtown Harbour Centre campus in the adjoining Spencer building and houses the Center for Dialogue and Canadas World.

The Vancouver Lookout tourist attraction, located atop the Harbour Centre business building, was officially opened on August 13, 1977 by Neil Armstrong, whose footprint was imprinted onto cement and was on display on the viewing/observation deck until disappearing during renovations.