[4] The series focuses primarily on a core group of eight medical students at Boréal Medical School: Nancy Siebolski (Angela Asher), Cameron Cahill (Jamie Spilchuk), Gary Frazier (Mark Coles Smith), Melanie Truscott (Melissa Jane Shaw), Charlie Rivière (Stéphane Paquette), Eva Malone (Andrea Menard), Gina Russo (Tamara Duarte) and Farida Farhisal (Rachelle Casseus).

In the final season, Eric Peterson joined the cast as Dr. Kesler, the head of a medical clinic where some of the students are doing their practical placements; his unpredictable performance as a doctor leads the interns to suspect that he may be suffering from the early stages of dementia, although he is eventually revealed as struggling with an addiction to prescription painkillers.

[5] In conjunction with the show's second season, Sudbury mayor Brian Bigger issued a civic proclamation declaring February 15, 2015 to be "Hard Rock Medical Day" in the city.

[5] In the show's third season, consistent with the third year of a medical program marking the shift from classroom-based learning to practical internship placements, most filming took place on or near the Canadore College campus in North Bay.

[14] Music used in the series was performed almost entirely by local artists from the region, including Patricia Cano, Kevin Closs, Brian Dunn, Ox, Pistol George Warren, Kate Maki, Frederick Squire, Derek Dino White, Hidden Roots Collective, Tasheena Sarazin and Carden Cove.