In the near future, a man called Harley Davidson travels from Texas to Burbank, California to reconnect with his old friend Robert Lee "Marlboro Man" Edison at their old haunt; Rock N' Roll Bar & Grille, owned by their mutual friend Jack Daniels, who holds animosity towards Harley over an affair he and his now-wife Lulu had years prior.

The bar has fallen on hard times, and the Great Trust Bank threatened foreclosure, planning to demolish the building to make way for a skyscraper.

Harley and Robert convince Jack to help them rob one of the Bank's armored cars to collect the funds necessary to renew the building's lease.

The bank's head of security Alexander is ordered by CEO Chance Wilder to recover the drugs and kill the thieves.

Harley takes Virginia to breakfast the next morning, during which she says that Crystal Dream is 100% addictive and causes lasting neurological damage and, eventually, death.

The two hop a freight train headed east after deactivating the tracker, but Marlboro leaves after telling Harley that they owe it to the dead friends who helped them to return to LA and settle things.

Wilder is unwilling to do so and orders his men to kill them when the pilot, paid off by Harley and Marlboro, appears hovering in his chopper outside.

Other songs in the film, but not included on the soundtrack are "Stop the World" by The Screaming Jets, "Wanted Dead or Alive" by Bon Jovi, and "Work to Do" and "The Better Part of Me" by Vanessa Williams.

[5] Vincent Canby of The New York Times wrote, "Mr. Rourke and Mr. Johnson handle their roles with more ease and humor than can be accommodated by a movie so stuffed with mindless fistfights, gunfights, helicopter chases, explosions and leaps from tall buildings.

"[7] Kim Newman of Empire wrote, "For a while, its crassness is amusing, but as the plot sets in, it gradually turns into a stultifying bore.

[11] Harley Davidson and the Marlboro Man was released to DVD by MGM Home Entertainment on February 20, 2001,[12] and on Blu-Ray by Shout!