Many famous people have lived or practised in Harley Street, including the Victorian Prime Minister William Ewart Gladstone, the artist J. M. W. Turner, and the speech therapist Lionel Logue.
In Jane Austen's Sense and Sensibility (1813), the Dashwood sisters, Lucy Steele, Mrs Jennings, Edward Ferrars, and others spend some of their free time there while in London.
In Agatha Christie’s The Secret of Chimneys (1925), Lord Caterham ruefully mentions that his doctor advised him to “avoid all worry.
In Henry James' "The Turn of the Screw" (1898), the wealthy uncle at the beginning of the work apparently has a house on Harley Street.
In Eoin Colfer's novel Artemis Fowl and the Eternity Code, the title character rents a cryogenic pod from a facility off Harley Street.
In Downton Abbey (2011), a fictional obstetrician with a practice on Harley Street Sir Philip Tapsell is hired by Lord Grantham to deliver the baby of his daughter Lady Sybil.
When another physician Dr. Clarkson notices signs of preeclampsia, Sir Tapsell and Lord Grantham ignore his warnings and suggestion to perform a Caesarean section.