Harran was inhabited during the Byzantine era in Syria, as attested by an inscription found in the village dedicated to the goddess Athena dating from 212 to 375 CE.

[2] By the late 6th century, Harran's inhabitants were Christians and the village was part of the Ghassanid tribal kingdom, a vassal of the Byzantines.

[3] The inscription describes a martyrium built by an Arab phylarch (equivalent to sheikh, chieftain) named Sharahil ibn Zalim.

[3]In 1596 Harran appeared in the Ottoman tax registers as part of the nahiya (subdistrict) of Bani Abdullah in the Hauran Sanjak.

They paid a fixed tax-rate of 40% on agricultural products, including wheat, barley, summer crops, goats and beehives, in addition to occasional revenues; the taxes totaled 3,350 akçe.