The Harriet Taylor Upton House is located in downtown Warren, on the northeast side of Mahoning Avenue near the municipal offices, an area known locally as "Millionaire's Row".

It is a 2+1⁄2-story wood-frame structure, with a hip roof, clapboarded exterior, and single-story porch across the front.

Original carrying Egyptian features, it was at some point given a Greek Revival makeover, the style it had when occupied by Harriet Taylor Upton.

[3] During Upton's term as treasurer of the National Woman Suffrage Association (1894–1910), the organization was headquartered in this house for part of that time (roughly 1903–1909).

Upton's leadership of the organization helped keep it afloat during a period in which relatively few gains were made toward women's suffrage, but gave it continuity between its early leaders and the subsequent successful campaigns for the vote.