Since 2012, it has been defined as part of the Harrisburg–York–Lebanon combined statistical area, which also includes York, Lebanon, and Adams counties.

[2] Harrisburg–Carlisle is located in the Susquehanna River's valley, which makes the terrain rolling, with occasional flat land and tall hills.

The Harrisburg metropolitan area has a humid continental climate, experiencing four mild seasons: summer, autumn, winter, and spring.

[15] The Harrisburg–Carlisle metropolitan area is served by a number of interstates, US routes, and state highways that help facilitate the movement of people and goods throughout the region.

[19] Some residents use Baltimore/Washington, Ronald Reagan Washington, and Philadelphia airports for a wider selection of destinations and airlines.

Amtrak's Keystone Service, which terminates at Harrisburg Transportation Center, allows for rail trips to points east, including Philadelphia and New York City.

Plans included a commuter rail line, called the Capital Red Rose Corridor, running from Lancaster to Harrisburg, with a possible extension to Carlisle.

CAT provides local and commuter bus service in eastern Cumberland and southern Dauphin counties.

The following is a list of non-profit colleges and universities within Harrisburg–Carlisle: The Harrisburg–Carlisle metropolitan area is located entirely within the Harrisburg–York–Lebanon media market.