Harrisburg is a village in Franklin and Pickaway counties in the U.S. state of Ohio.

Harrisburg was founded in 1836 by Joseph Chenowith, and surveyed and platted by Frederick Cole.

Prior to the laying out of the village, the area was known as Darby Cross Roads.

The post office was, for an unknown reason, discontinued or decommissioned on August 26, 1836, but was quickly re-established on October 21, 1836.

[7] From the outset in 1836 Harrisburg was known as a lively village, and then held about thirty families.

[5] According to the United States Census Bureau, the village has a total area of 0.15 square miles (0.39 km2), all land.

30.4% of all households were made up of individuals, and 10.8% had someone living alone who was 65 years of age or older.