Millarde was born in Cincinnati, Ohio, and began his acting in film in 1913 with Kalem Studios in New York City.

Amongst Millarde's other works were Over the Hill to the Poorhouse (1920) and the thriller My Friend the Devil (1922) based on the French novel, Le Docteur Rameau by Georges Ohnet.

Millarde directed his last film in 1927 and died of a heart attack in New York City in 1931.

He was married to actress June Caprice (1895-1936), whom he had directed in eight films for Fox.

Raised by her grandparents in Long Island, New York, she became a cover girl known as Toni Seven.