Ultimately coming under Allgemeine-SS administration, it became responsible for orchestrating the implementation of Nazi Lebensraum (English: living-space) policies in Eastern Europe during World War II.

In June 1941 VOMI was absorbed into the office of the Reich Commissioner for the Consolidation of German Nationhood (RKFDV) run by Himmler.

As RKFDV chief, Himmler authorized the SS-Einsatzgruppen (mobile death squads) and other SS police units to round up and kill Jews, Slavs and Roma.

With Hitler's blessing, Himmler now had complete control over VoMi, ethnic Germans outside Imperial Germany policy and living space programs.

In the later period of the war, Amt II's importance increased as it was responsible for allocating Volksdeutsche to the Reich Labor Service.

("Resettlement") This department was primarily responsible for handling the massive germanisation operation to settle Volksdeutsche throughout Germany and Occupied Europe.

A VoMi unit, Sonderkommando R (Russland), institutional successor to Einsatzgruppe D in the Transnistria area, carried out numerous massacres of Jews during the first half of 1942.

The victims were deportees from Rumanian-controlled territory, it being Marshal Ion Antonescu's policy to racially "cleanse" the Rumanian nation.

Perhaps oddly, Radu Ioanid's The Holocaust in Romania: The Destruction of Jews and Gypsies Under the Antonescu Regime, 1940-1944 does not cover Sk-R, nor does Valdis O. Lumen's book dedicated to VoMi.

After the war, a memorandum prepared by Frank on September 26, 1942, detailed instructions on dealing with this ill-gotten wealth; which even included collecting the underwear of victims.

The memorandum refuted claims that organizations like VoMi had no knowledge that Jews were being murdered en masse in the extermination camps.