[2] In June 2022, Matthews was named as the captain of the West Indies women's cricket team, taking over from Stafanie Taylor.

[6] An early memory for Matthews is joining in on games of cricket between her father and older brother, Wayne, at home after school.

[5] After Matthews started attending People's Cathedral Primary School, which was next door to her home, an opportunity arose for her to play the game formally.

[12] Soon after starting at Harrison College, Matthews joined the school's previously all-boys' Under-13 team as an opening batter.

At the age of 18, she had already played in the Men's First Division for the Pickwick Club, alongside male players including West Indies batter Shai Hope.

[25] Matthews made her One Day International (ODI) debut a few months later,[26] scoring 55 runs from 86 balls in the first game of a four-ODI series against Australia.

[29] Matthews has been a regular for the West Indies since her debut,[25][26] and was a key member of the team that won the 2016 World Twenty20, scoring 66 runs from 45 balls in the final.

[39] In October 2021, she was named in the West Indies team for the 2021 Women's Cricket World Cup Qualifier tournament in Zimbabwe.

[43] Matthews played in her 100th WT20I in the final group match against England, scoring 52 off 38 balls as West Indies clinched a semi-final place with a six-wicket win.

[44][45] On 22 September 2018, Matthews scored her maiden ODI hundred against South Africa in front of her home crowd at Bridgetown.

[59][60] At the inaugural Invitational, held in Dubai in May 2022, she took 5/123 in five matches and made 153 runs at 30.60 including two half centuries:[59] 58 against the Falcons[61] and 52 against Barmy Army.

[63] As an athlete, Matthews competed in the javelin throw, and represented Barbados in a number of international meets and competitions.