Headington School was founded in 1915 by a group of evangelical Christians to provide "a sound education for girls to fit them for the demands and opportunities likely to arise after the war".

It started at Headington Lodge on Osler Road with ten boarding and eight-day girls.

[1] The preparatory school is located on a separate site across the junction where Headington Road and Headley Way meet.

Its pupils uses some facilities of the senior school, such as the swimming pool, playing field, all-weather surface and theatre.

There are 23 acres of grounds and playing fields, tennis courts, swimming pool and a floodlit Astroturf pitch.

[15] It has also performed well in the South of England Indoor Rowing Championships, winning five overall classes in 2008[16] and finishing runners-up in 2010.

[17] Two of its members were chosen to represent Great Britain at the 2010 Summer Youth Olympics in Singapore and claimed a gold medal in the girls' pair category.

[18] In 2013 seven Headington girls won their category in the Oxford Music Festival and the sixth form vocal ensemble The Eleven received the top choral prize.