Initial investments were made from Polaris Venture Partners,[3] Sequoia Capital,[4] The Carlyle Group,[5] and Allen & Company.

InterActiveCorp made a significant minority investment in the company in 2008,[6] and the initial group of investors joined in the round of funding to reinvest in HealthCentral.

[13] Amulet Capital Partners, a private equity firm focused on healthcare, acquired Remedy Health Media in 2021.

[19] Founded in 1995, TheBody.com[20] provides medically reviewed information as well as news, support, and personal experiences on HIV and related issues to help people diagnosed with HIV/AIDS.

[22] PatientPower.info provides patients and caregivers dealing with cancer and other serious and chronic conditions with information from healthcare experts as well as personal accounts to assist them to get the best medical treatment possible.

[29][30] In 2021, HealthCentral.com won the long-form feature category in the Folio Eddie & Ozzie Awards, which recognize excellence in both print and digital editorial content and design.