The current building was constructed in 1939 as the administrative headquarters of Canadian Breweries Limited, having previously been the site of a public school.
Right next to this building, also built partially on the site of the old public school, was a new bottling plant for O'Keefe Breweries.
In the 1960s, Toronto Metropolitan University, then known as the Ryerson Polytechnic Institute, expressed an interest in buying the site of the O'Keefe Brewery.
The institute used the former bottling plant as the home of the Faculty of Business, and turned the main site of the O'Keefe Brewery into a parking lot.
In 2006, renovations of Heaslip House were completed, and in 2012, the university announced that it would be the new home of the G. Raymond Chang School of Continuing Education.