In 2009 the Trust was dissolved and the hospital is now managed by Cardiff and Vale University Health Board.

[6][7] The Welsh Board of Health and University Grants Committee outlined the criteria for an 820-bed hospital in 1953 and proposed a competition for architects to submit plans, although this was not sanctioned until 1958 due to concerns over funding.

[7][8] The competition was launched in April 1959 and judged by Sir Percy Thomas (Past President of the Royal Institute of British Architects), J.H.

[9][10][11] The architecture of the hospital is dominated by long, parallel slabs, one eight-storied, the other five-storied.

The Prince Charles Hospital in Merthyr Tydfil, Wales, completed in 1975, followed a similar design.

[1][14] In 2005, Base Structures completed a £1 million project by to construct a walkway joining separate parts of the hospital.

The modular building houses a multi-disciplinary model of care, with physiotherapists, occupational therapists, dieticians, pharmacists, healthcare support workers and registered nurses all working in the facility.

[21] The unit was scheduled to have a £3.4 million refit in 2013, but this was rescheduled due to increased demand on the service and the disruption the work would cause.

[22] In July 2020, the "call before you walk" system was adopted: less severely ill patients are directed to other services and those who need to be in A&E are given an appointment.

The company cancelled parking charge notices issued up to the end of March 2016, leaving more than 100,000 unpaid tickets outstanding.

[34] In June 2010, surgery was discontinued temporarily after surgeons complained the instruments they had been given had not been sterilized properly and were visibly dirty.