Heaton Mersey railway station was opened on 1 January 1880 by the Midland Railway[1] and lay on the newly opened Manchester South District Line which ran from Heaton Mersey East Junction to Chorlton Junction and on to Manchester Central station.

[1] The main station building was a substantial brick-built structure located on the east (southbound) side of the line.

A footbridge led across the twin railway tracks to the northbound platform which was provided with a smaller brick-built shelter.

Station staff could use a wooden boarded crossing at the north end of the facility.

These continued to run after the closure of the station until 1967, with line closing to all traffic two years later.