In August 2016, Peralejo participated in the Philippine reality show Pinoy Big Brother: Lucky 7, with the moniker "Mommy's Angel ng Makati" where she rose to prominence.

She formed a close bond with her fellow teen housemates Marco Gallo and Edward Barber while inside the house.

[13] After her stint in Pinoy Big Brother: Lucky 7, Peralejo had a small role in Maalaala Mo Kaya: Karnabal episode in December 2016, as Ramon's daughter.

She was cast in her first Ipaglaban Mo episode entitled Hawig where she played Rachel, the niece of Janice De Belen's character.

In August, Peralejo played the role of Hershey in the movie Harry and Patty where she worked with Mark Neumann and her PBB-co housemate Marco Gallo.

[14] In the same year, Peralejo starred in a Maalaala Mo Kaya episode entitled Basketball Court opposite Joshua Colet.

In the same year, Peralejo played the biological daughter of Iza Calzado who is suffering from mental illness in an episode of Maalaala Mo Kaya entitled Medalya.

Her acting breakthrough came in her performance in the 2022 Metro Manila Film Festival movie Nanahimik ang Gabi along with Ian Veneracion and Mon Confiado, which she scored a Best Actress nomination.

Peralejo played Luna in the live adaptation of The Rain In España which was part of the University Series and was streamed on Viva One.

Peralejo joined the cast of Linlang alongside Kim Chiu, Paulo Avelino, JM De Guzman, and Maricel Soriano which was streamed on Amazon Prime Video.

Peralejo and Gallo paired up once again in the movie Men Are From QC, Women Are From Alabang which was a live adaptation of the book written by Stanley Chi.

Later that year, Peralejo starred in the movie Fruitcake alongside an ensemble cast that includes Joshua Garcia, Ria Atayde, Empoy Marquez, Enchong Dee, Jane Oineza and Dominic Ochoa among others.