She previously served as the United States Assistant Secretary of the Army for Acquisition, Logistics, and Technology ASA(ALT) from 2012 to January 30, 2016.

In 2019, Shyu was elected as a member of the National Academy of Engineering for the development of innovative radar/electrooptics/infrared systems in support of the US Army and Air Force.

[2] She was a member of the United States Air Force Scientific Advisory Board from 2000 to 2010, serving as its vice-chairman from 2003 to 2005 and as its chairman from 2005 to 2008.

[2] President Barack Obama nominated her to be an Assistant Secretary of the Army for Acquisition, Logistics, and Technology in the US Defense Department in February 2012.

[5] On April 27, 2021, President Joe Biden nominated Shyu to be the next Under Secretary of Defense for Research and Engineering.