The daughter of Jewish immigrants from Hungary, Weisel credited her mother Rachel's simple, elegant style and her father David, who had a textile business, with instilling a love and appreciation of beautiful fabrics.

Her initial concept was inspired by the movement and diaphanous costumes of dancers as well as by her own personal search for youthful, elegant designs that were modern and unstructured.

The dress that launched her career featured a knitted cashmere bodice and silk chiffon skirt, simply held together by a satin ribbon.

The collection was soon carried at national retailers Neiman Marcus, Barneys New York, Bergdorf Goodman, Saks Fifth Avenue, Bloomingdale's, and Marshall Field's; United Kingdom-based Harrods and Harvey Nichols; as well as the United States specialty stores Stanley Korshak, Mitchells, Richards, and Linda Dresner.

[5][6][7][8] As part of the debut collection, Weisel created a wrap for the Susan G. Komen Breast Cancer Foundation, for which a portion of proceeds benefited the organization.

Weisel's work has been featured in major motion pictures, including: Celebrities Brooke Shields, Faith Hill, Sandra Bullock, Vanessa Williams, Oprah Winfrey, Catherine Zeta-Jones, Elizabeth Hurley, Salma Hayek, Debra Messing, Sharon Stone, Joan Allen, Lisa Kudrow, and Sofía Vergara have all worn Heidi Weisel; as have fashion industry icons Kate Spade and Bobbi Brown.