She has also played the roles of Jane Martin on the Showtime American period drama television series Masters of Sex, Olivia Graves on Graves and Amy Breslin on The Good Fight.

Additionally, she is known for her work on Broadway, in particular for originating the roles of Olive Neal in Bullets Over Broadway and Evelyn Williams in American Psycho, as well as for originating G(a)linda in the second National Tour of Wicked.

[2] In 2013, Yorke was cast in a recurring role as Jane Martin on the Showtime period drama television series, Masters of Sex.

Since 2019, she has starred as Brooke Dubek on Comedy Central/HBO Max television series The Other Two, which was renewed for a third season in September 2021.

[8] In January 2022, she announced her pregnancy on Instagram,[9] and in June 2022, the couple welcomed a son.