Heleen Margriet Dupuis (born 30 May 1945) is a Dutch ethicist, professor, and politician who served in the Senate from 1999 to 2015 as part of the People's Party for Freedom and Democracy (VVD).

She served as chairman of the Dutch Voluntary Euthanasia Association from 1981 to 1985, and has also served as chairman of the Alzheimer's Council of the Netherlands; she cites the death of her first husband from dementia in her support of voluntary euthanasia.

[2] After her time as chair, Dupuis became a professor of medicine and ethics at Leiden University beginning in 1986.

[3] Dupuis's political career began in 1999 when she was named to the Senate as a member of the VVD.

Her focuses as a Senator were on public healthcare and higher education, in particular wanting the budget moved from healthcare to education, as well as a focus on stricter ethics in medicine.