As a result of the first hand experience she gained in working with mentally ill women in poverty, she was inspired to start her own facility.

[3][7] In 1897, she moved to Hove, East Sussex, where she and Mabel Jones set up the Lewes Road Dispensary for Women and Children, a GP surgery in Roundhill Crescent.

[9][5][4][7] The Lady Chichester Hospital was first established in a small house at 101 Roundhill Crescent, offering free or low-cost care in a mostly female environment for up to ten patients.

It soon relocated to a larger house at 70 Brunswick Place in Hove in 1911, with capacity to treat 38 patients, before finally finding a permanent home in 1920 with the purchase of Aldrington House on New Church Road in Brighton; the hospital would remain there beyond Boyle's retirement in 1948, when it was absorbed into the newly formed National Health Service.

[10] The building still hosts a mental health clinic, supporting people over 65 who are undergoing early signs of psychosis.

[14] Boyle worked at this facility for fifty years and remained an integral part of the practice through location changes and expansions.

[3][12] Boyle never married or had children, but she lived with her long-time companion, Marguerite du Pre Gore Lindsay, for the final seventeen years of her life.