Helen U. Esuene listenⓘ (born 23 November 1949[1]) is a former Nigerian civil servant who was appointed Minister of State for Health, and later Minister of Environment and Housing in the Cabinet of President Olusegun Obasanjo between 2005 and 2007.
Shortly after she married the former military governor of the old Cross River State, Chief Udoakaha Esuene, who died in 1996.
She went into business, starting with human resource management for Mobil Producing.
After a cabinet reshuffle in January 2007, Esuene was given an expanded portfolio as Minister of Environment and Housing.
Helen Essuene was the candidate for the Senatorial seat of Akwa Ibom South in the April 2011 Nigeria general elections, running on the People's Democratic Party (PDP platform).