[2] With some stage experience, Twelvetrees went to Hollywood with a number of other actors to replace the silent stars who could not or would not make the transition to talkies.

However, she was signed by Pathé shortly thereafter, and along with Constance Bennett and Ann Harding, Twelvetrees starred in several lachrymose dramas, not all of which were critically acclaimed.

With the arrival of Katharine Hepburn at RKO, Twelvetrees left the studio to freelance (Harding and Bennett would also subsequently depart).

The 1930 film Her Man set the course of Twelvetrees' screen career, and she was cast in a series of roles portraying suffering women fighting for the wrong men.

Later she appeared with Spencer Tracy in Now I'll Tell (also known as When New York Sleeps); with Donald Cook in The Spanish Cape Mystery; and with Maurice Chevalier in Paramount's A Bedtime Story.

She also starred in two Metro-Goldwyn-Mayer films, which prompted author John Douglas Eames to note that she "had a gift for projecting emotional force with minimal visible effort.

"[3] In 1936, Twelvetrees traveled to Australia to star in the Cinesound Studios production Thoroughbred, about the rise of a Melbourne Cup winning racehorse.

[5] Twelvetrees left film in favor of summer stock and made her Broadway debut in Jacques Deval's Boudoir in 1941.

She continued to act occasionally, such as in the role of Blanche DuBois in A Streetcar Named Desire in summer stock in Sea Cliff, New York in August 1951.

[5] Fellow cast member Naomi Caryl recalled that Twelvetrees had "... the saddest eyes I'd ever seen ... it was also obvious that she had an extremely fragile psyche.

[10][11] Twelvetrees married again in April 1931, this time to WWI Marine Corps veteran Frank "Jack" Bryan Woody.

Woody was a Hollywood stuntman and realtor, who would later become a full-time actor and seasonal hunting guide in California's Sierra Nevada.