[2][3] She also had small parts in two episodes of a German TV series, Die Spezialisten – Im Namen der Opfer.

In the drama film System Crasher, written and directed by Nora Fingscheidt, which premiered in February 2019 at the Berlinale, Zengel plays the leading role of "Benni", an aggressive and traumatised nine-year old.

In this adaptation of the 2016 novel of the same name by Canadian-American writer Paulette Jiles, which starred Tom Hanks as Captain Jefferson Kidd, Zengel stars as a 10-year-old German orphan named Johanna Leonberger who was raised by the Kiowa; most of her performance is in the Kiowa language[6][7] For her performance, Zengel received nominations for a Golden Globe Award and Screen Actors Guild Award for Best Actress in a Supporting Role.

In 2021, Zengel appeared as Nina Cutter in A Christmas Number One alongside Freida Pinto and Iwan Rheon, a heartfelt romantic comedy about a young woman trying to save her uncle from himself before she succumbs to a terminal illness.

The film was directed by Chris Cottam and written by Robert Chandler, Keiron Self and Giles New, and features performances by the fictitious artists, 5 Together, Scurve and Ranelle Spear.