The series follows Meisuke Nueno, aka Nūbē, the homeroom teacher for Class 5–3 at Dōmori Elementary.

A new anime television series adaptation produced by Studio Kai is set to premiere in July 2025.

In May 2014, a direct manga sequel has started with the premise of ten years having passed, with Kyoko becoming a teacher at the Dōmori Elementary and Nūbē returning to the school from Kyushu.

A sequel titled Jigoku Sensei Nūbē S was published in Saikyō Jump from August 2018 to April 2021.

What seems like a normal day at Dōmori Elementary is disrupted by some weird phenomenon, usually targeting one of Nūbē's own students.

Nūbē is forced into action, most often using the power of the Demon's Hand to assist in solving the problem, but occasionally the solution lies either in another of his spiritual weapons, or somehow reasoning with or appeasing the threatening entity.

[13] The manga was then transferred to Shueisha's Grand Jump,[14] but renamed as Reibaishi Izuna: Ascension, starting on November 16, 2011.

[20] A one-shot chapter Jigoku Sensei Nūbē: Ōmagatoki was published in Grand Jump on April 2, 2014.

[21] A to sequel to the original series, Jigoku Sensei Nūbē Neo, started in Grand Jump Premium on May 28, 2014.

[16] Jigoku Sensei Nūbē Neo was simultaneously serialized in Shueisha's shōnen manga magazine Saikyō Jump from August 5, 2016, to June 1, 2018.

[36] It is set to premiere in July 2025 on TV Asahi's brand new IMAnimation W [ja] programming block.

Nūbē later appeared as a playable character in the 2014 PlayStation 3/PlayStation Vita game J-Stars Victory VS.[46] A ten-episode television drama adaptation was broadcast on Nippon TV from October 11 to December 13, 2014.